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Title: Cytotoxic and Anti-Inflammatory Sesquiterpenes from the Whole Plants of Centipeda minima. Author: Xue PH, Zhang N, Liu D, Zhang QR, Duan JS, Yu YQ, Li JY, Cao SJ, Zhao F, Kang N, Qiu F. Journal: J Nat Prod; 2021 Feb 26; 84(2):247-258. PubMed ID: 33533247. Abstract: Sixteen new sesquiterpene lactones (1-16) along with 13 known analogues (17-29) were isolated from the whole plants of Centipeda minima. The structures of 1-16 were delineated by the combination of NMR spectroscopic experiments, HRESIMS, single-crystal X-ray diffraction analyses, and ECD spectra. Compounds 23-26 showed potent cytotoxicity against Hela, HCT-116, and HepG2 cells with IC50 values of 0.8-2.6, 0.4-3.3, and 1.1-2.6 μM, respectively. Compounds 8, 15, and 24 exhibited significant inhibitory activity on the production of nitric oxide in the lipopolysaccharide-activated RAW 264.7 mouse macrophage cell line, with IC50 values ranging from 0.1 to 0.2 μM.[Abstract] [Full Text] [Related] [New Search]