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  • Title: Organocatalytic asymmetric allylic alkylation of 2-methyl-3-nitroindoles: a route to direct enantioselective functionalization of indole C(sp3)-H bonds.
    Author: Xu JX, Chu KT, Chiang MH, Han JL.
    Journal: Org Biomol Chem; 2021 Feb 25; 19(7):1503-1507. PubMed ID: 33533776.
    Abstract:
    We here described a direct catalytic asymmetric functionalization of 2-methylindoles using organocatalysis. An efficient asymmetric allylic alkylation reaction with respect to 2-methyl-3-nitroindoles and racemic Morita-Baylis-Hillman carbonate has been achieved by using a chiral biscinchona alkaloid catalyst, which provided the functionalized indole derivatives in good yields and enantioselectivities.
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