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  • Title: Comparison of the trichothecenes deoxynivalenol and T-2 toxin for their effects on brain biogenic monoamines in the rat.
    Author: Fitzpatrick DW, Boyd KE, Watts BM.
    Journal: Toxicol Lett; 1988 Mar; 40(3):241-5. PubMed ID: 3354008.
    Abstract:
    Male Sprague-Dawley rats (180 g) were orally dosed with deoxynivalenol (DON) and T-2 toxin at 2.5 mg kg-1 body weight. Brains were collected 24 h postdosing, dissected into five brain regions and analyzed for biogenic monoamines by high performance liquid chromatography with electrochemical detection. DON and T-2 toxin treatment resulted in significantly elevated concentrations of the indoleamines, serotonin (HT) and 5-hydroxy-3-indoleacetic acid (HIAA) in all brain regions examined, whereas norepinephrine (NE) and dopamine (DA) regional concentrations were not significantly altered. These results indicate that DON and T-2 toxin influence brain biogenic monamine metabolism, and suggest that the central nervous system (CNS) actions of these trichothecenes are similar.
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