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  • Title: Pressure, biochemical, and culture characteristics of CSF associated with the in utero drainage of various fetal CNS defects.
    Author: Simpson GF, Edwards MS, Callen P, Filly RF, Anderson RL, Golbus MS.
    Journal: Am J Med Genet; 1988 Feb; 29(2):343-51. PubMed ID: 3354605.
    Abstract:
    An attempt has been made to begin delineation of the in utero dynamics of fetal intracranial fluid in the presence of brain malformations. In a series of patients with fetal CNS defects, cephalocentesis was performed at the time of therapeutic abortion or to facilitate vaginal delivery. Intracranial CSF pressures and volumes were quite variable. There did not appear to be any discernible correlation between the type of lesion and the intracranial pressure. Fetal CSF glucose levels were moderately depressed and protein concentrations were very high. Neither virus nor bacteria were cultured from fetal CSF or amniotic fluid of any patients in this series.
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