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  • Title: Contractile effects of manganese on taenia of guinea pig cecum.
    Author: Lategan TW, Brading AF.
    Journal: Am J Physiol; 1988 Apr; 254(4 Pt 1):G489-94. PubMed ID: 3354670.
    Abstract:
    The present study was undertaken to examine Mn as a contractile agent in its own right in the absence of extracellular Ca and after the depletion of Ca from agonist-releasable stores. The results show that isolated strips of taenia coli depolarized by high-K, Ca-free solution will contract when Mn is present. Similarly, carbachol will evoke contractions in tissues incubated in Ca-free, Mn-containing solutions. In addition, it seems possible to stimulate contraction by releasing Mn from an agonist-releasable intracellular store in the absence of extracellular Ca and Mn. Therefore the possibility exists that cations employed as Ca antagonists may in fact support contraction.
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