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  • Title: Chemiluminescence immunoassay for progesterone in plasma incorporating acridinium ester labelled antigen.
    Author: Miller SA, Morton MS, Turkes A.
    Journal: Ann Clin Biochem; 1988 Jan; 25 ( Pt 1)():27-34. PubMed ID: 3355086.
    Abstract:
    A sensitive, solid-phase chemiluminescence immunoassay suitable for determining progesterone concentrations in plasma has been developed. The solid-phase antiserum was prepared by coupling a monoclonal progesterone-antibody, raised against a progesterone-11 alpha-hemisuccinyl/bovine serum albumin conjugate, to cyanogen bromide activated cellulose. An 11 alpha-progesteryl-2-carboxymethyltyramine-4-(10-methyl)-a cri dinium-9-carboxylate conjugate was used as the chemiluminescent label. The assay had a lower limit of sensitivity of 3 pg/assay tube and satisfied accepted validation criteria. Progesterone concentrations determined by chemiluminescence assay were in good agreement not only with a radioimmunoassay in routine use but also with a gas chromatography-mass spectrometry procedure.
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