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  • Title: [Stomach tumors in rats induced by a single administration of N-methyl-N-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea].
    Author: Vol'fson NI, Pliss GB, Petrov AS, Zaozerskaia LA, Kalinovskiĭ VP.
    Journal: Vopr Onkol; 1988; 34(3):330-4. PubMed ID: 3358297.
    Abstract:
    The pathologic characteristics of gastric tumors induced by single injections of N-methyl-N'-nitro-N-nitrosoguanidine (15 mg) solution and N-methyl-N-nitrosourea (10 mg) solution in 0.1 ml dimethylformamide were studied in 23 noninbred rats. The chemicals were injected into the antropyloric segment of the stomach. By months 11-15, specific changes in the glandular epithelium had developed at that site in 20 rats: dysplasia--in 6, precancer--7, and adenocarcinoma in 7 animals. Also, there were papillomas (6), squamous cell carcinoma (3), precancer and sarcoma (4) in various segments of the organ.
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