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  • Title: Increased sulfate uptake in skin fibroblasts isolated from cystic fibrosis patients.
    Author: Elgavish A, Meezan E.
    Journal: Biochem Biophys Res Commun; 1988 Apr 15; 152(1):99-106. PubMed ID: 3358775.
    Abstract:
    Sulfate uptake into skin fibroblasts from patients with cystic fibrosis is increased. Sulfate transport studies were carried out in skin fibroblasts isolated from age/sex matched cystic fibrosis and normal subjects. Sulfate transport occurred mainly via a carrier-mediated proton-stimulated S04(2)-/Cl-exchange. The capacity (Vmax) of the uptake system operating at physiological concentrations of sulfate was stimulated in cystic fibrosis, but the affinity of the carrier for sulfate was not altered.
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