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  • Title: [Multiple colorectal cancers: properties and long-term prognosis].
    Author: Raab R, Werner U, Löhlein D.
    Journal: Chirurg; 1988 Feb; 59(2):96-100. PubMed ID: 3359877.
    Abstract:
    In our own patient population with primary colorectal cancer (n = 1352, 1971-1984) we analyzed the frequency, characteristics and prognosis of multiple carcinomas. The overall incidence was 7.3% (4.5% synchronous and 2.8% metachronous carcinomas). Compared to single cancer synchronous tumors had a worse and metachronous tumors had a better 5 year-prognosis (58%, 43% and 86% respectively). This suggests that synchronous and metachronous colorectal carcinomas may be two biologically separate entities. Conclusions from our observations are discussed in regard to diagnosis, therapy and follow-up.
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