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  • Title: Criteria for the cure of acromegaly: comparison between basal growth hormone and somatomedin C plasma concentrations in active and non-active acromegalic patients.
    Author: Giannella-Neto D, Wajchenberg BL, Mendonça BB, Almeida SF, Macchione M, Spencer EM.
    Journal: J Endocrinol Invest; 1988 Jan; 11(1):57-60. PubMed ID: 3361077.
    Abstract:
    Fasting plasma growth hormone (GH) and somatomedin C (SmC) levels were compared as criteria for the cure of acromegaly in 7 untreated and 16 treated acromegalic patients studied 1 to 16 yr after pituitary surgery and/or radiotherapy. The patients without active disease presented a significant correlation between GH and SmC. Only when basal GH was lower than 2.5 ng/ml were SmC values within the normal range. The subjects with active acromegaly (both treated and untreated) presenting GH higher than 5 ng/ml did not show any correlation between GH and SmC levels.
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