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  • Title: A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy.
    Author: Li Y, Wang C, Zhou L, Wei S.
    Journal: Chem Commun (Camb); 2021 Mar 28; 57(25):3127-3130. PubMed ID: 33630986.
    Abstract:
    A 2-pyridone modified zinc phthalocyanine (denoted ZnPc-PYR) achieves a one stone for three birds outcome in the photodynamic therapy (PDT) treatment of cancer. ZnPc-PYR can be excited by both 665 and 808 nm light to treat superficial and deep tumors, store and slowly release singlet oxygen (1O2) to improve its utilization and downregulate the HIF-1 (hypoxia-inducible factor 1) expression level to enhance the tumor cell's sensitivity to PDT treatment under hypoxic conditions.
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