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  • Title: Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp.
    Author: Xie X, Lu S, Pan X, Zou M, Li F, Lin H, Hu J, Fan S, He J.
    Journal: J Nat Prod; 2021 Feb 26; 84(2):537-543. PubMed ID: 33631936.
    Abstract:
    A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
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