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  • Title: Inhibition of the rat hepatic mixed-function oxidases by in vivo administration of clotrimazole.
    Author: Rodrigues AD, Waddell PR, Ioannides C.
    Journal: Res Commun Chem Pathol Pharmacol; 1988 Mar; 59(3):403-6. PubMed ID: 3363224.
    Abstract:
    The ability of the 1-substituted imidazole antifungal agent clotrimazole to inhibit the rat hepatic microsomal mixed-function oxidases was investigated in rats pretreated with either phenobarbital or 3-methylcholanthrene. When administered to 3-methylcholanthrene-pretreated animals, clotrimazole inhibited the O-deethylations of ethoxyresorufin and ethoxycoumarin. An even more marked inhibition of the dealkylation of pentoxyresorufin and O-deethylation of ethoxycoumarin was observed in phenobarbital-pretreated rats. It is concluded that administration of clotrimazole to rats gives rise to a marked inhibition of the hepatic mixed-function oxidases, and especially of the cytochrome P450 II B family of haemoproteins.
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