These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hodgkin and Reed-Sternberg cell associated monoclonal antibodies HRS-1 and HRS-2 react with activated cells of lymphoid and monocytoid origin.
    Author: Pfreundschuh M, Mommertz E, Meissner M, Feller AC, Hassa R, Krueger GR, Diehl V.
    Journal: Anticancer Res; 1988; 8(2):217-24. PubMed ID: 3364933.
    Abstract:
    The two monoclonal antibodies HRS-1 and HRS-2, which were obtained after immunization with the Hodgkin's derived cell line L428, detect different epitopes on a 120 kd antigen. This antigen is present on Hodgkin- and Reed-Sternberg (H&RS) cells in all subtypes of Hodgkin's lymphoma and on large cell anaplastic non-Hodgkin's lymphomas. The H&RS- associated 120 kd antigen appears to be a non-lineage specific activation antigen, as it is not present on normal B and T lymphocytes or monocytes, but appears on these cells after activation. Because of their restricted reactivity with H&RS cells, HRS-1 and HRS-2 alone or in combination may be helpful for immunoimaging and immunotherapy of Hodgkin's lymphomas.
    [Abstract] [Full Text] [Related] [New Search]