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  • Title: Effects of oxiracetam-scopolamine combinations on shuttle-box avoidance acquisition in mice.
    Author: Sansone M, Libri V, Pavone F, Ammassari-Teule M.
    Journal: Arch Int Pharmacodyn Ther; 1988; 291():208-16. PubMed ID: 3365063.
    Abstract:
    The nootropic drug oxiracetam and the anticholinergic agent scopolamine were tested, alone or in combination, on shuttle-box avoidance acquisition and locomotor activity in mice of the CD-1 strain. Both drugs, given separately, slightly but significantly enhanced avoidance performance, but only scopolamine increased locomotor activity. Combinations of the 2 drugs, in some instances, enhanced avoidance performance more than drugs given separately, but the disinhibitory property of scopolamine makes it difficult to understand the role played by cholinergic mechanisms in these effects.
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