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  • Title: [Value of esogastroduodenal endoscopy with staged biopsies in children with Crohn's disease].
    Author: Mashako LM, Mougenot JF, Sonsino E, Cezard JP, Charritat JL, Foucaud P, Navarro J.
    Journal: Arch Fr Pediatr; 1988 Jan; 45(1):11-4. PubMed ID: 3365099.
    Abstract:
    An upper gastrointestinal endoscopy with multiple biopsies was performed in 19 children suspected of Crohn disease (CD) who had also undergone X-ray investigations and colonoscopy with multiple biopsies. Biopsies were performed in pathological and/or normal mucous areas. Upper gastrointestinal endoscopy showed macroscopic changes in 7 children (37%). Histologic examinations of the upper gastrointestinal tract were normal or showed only non specific changes in 12 cases (63%). Histopathologic changes specific for CD were found in 7 cases (37%), while specific histologic changes were identified at the rectal or colic level in 3 of these 7 cases only. Thus, upper gastrointestinal endoscopy with multiple biopsies was most useful for the diagnosis of CD, since it was the only diagnostic means in 4 cases. It should be systematically performed when CD is suspected.
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