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  • Title: Development of a piperazinyl-NBD-based fluorescent probe and its dual-channel detection for hydrogen sulfide.
    Author: Pei S, Li J, Zhang C, Liang W, Zhang G, Shi L, Wang W, Shuang S, Dong C.
    Journal: Analyst; 2021 Apr 07; 146(7):2138-2143. PubMed ID: 33651055.
    Abstract:
    To selectively detect H2S based on the thiolysis reaction of 7-nitro-1,2,3-benzoxadiazole (NBD), amines attracted increasing attention since NBD amine is regarded as a new H2S reaction site. Herein, a novel fluorescent probe, triphenylamine piperazine NBD (TPA-Pz-NBD), was developed. The results showed that it exhibited high selectivity towards H2S via fluorescence spectroscopy and solution color. Furthermore, TPA-Pz-NBD not only detected H2S by a dual-channel, turn-on fluorescence signal at 500 nm and turn-off fluorescence signal at 545 nm, respectively, but also displayed a wide detection range of 0-125 μM. In addition, living cell imaging results indicated that TPA-Pz-NBD holds potential for the detection of intracellular H2S.
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