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  • Title: Effects of antibodies against odorant binding proteins on electrophysiological responses to odorants.
    Author: Price S, Willey A.
    Journal: Biochim Biophys Acta; 1988 May 12; 965(2-3):127-9. PubMed ID: 3365448.
    Abstract:
    Monoclonal antibodies against two olfactory mucosal proteins, one with affinity for anisole-like and the other for benzaldehyde-like compounds, were applied to mouse olfactory epithelium. Responses to three odorants (anisole, benzaldehyde and amyl acetate) were measured. Of 26 antibodies, three (12%) inhibited responses only to the odorant with affinity for the antigen, nine (35%) inhibited responses to all three odorants, and 14 (54%) were without effect. None reduced responses by as much as 50%. The data support the hypothesis that there is a class of related proteins in olfactory neuronal cell membranes that function as receptor molecules and that other mechanisms also mediate odorant stimulation.
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