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  • Title: Acute visual and auditory neurotoxicity in patients with end-stage renal disease receiving desferrioxamine.
    Author: Cases A, Kelly J, Sabater J, Campistol JM, Torras A, Montoliu J, López I, Revert L.
    Journal: Clin Nephrol; 1988 Apr; 29(4):176-8. PubMed ID: 3365862.
    Abstract:
    We report 5 cases of acute visual and auditory neurotoxicity in patients with end-stage renal disease receiving desferrioxamine. Four patients complained of visual toxicity characterized by a decrease in visual acuity, loss of color vision and night blindness. In these patients there was a decrease in visual acuity, and the Farnsworth's test revealed a tritanopy (yellow-blue axis impairment); 1 patient also showed retinal pigmentary changes. A fifth patient complained of bilateral and severe neurosensorial deafness. Patients improved clinically upon drug-withdrawal. We recommend careful monitoring of audiovisual toxicity in patients with end-stage renal disease receiving this drug.
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