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  • Title: Pregnancy in women with diffuse mesangial proliferative glomerulonephritis.
    Author: Packham DK, North RA, Fairley KF, Whitworth JA, Lloren PR, Lee E, Kincaid-Smith P.
    Journal: Clin Nephrol; 1988 Apr; 29(4):193-8. PubMed ID: 3365864.
    Abstract:
    The clinical course of 168 pregnancies in 91 women with non-IgA diffuse mesangial proliferative glomerulonephritis has been analyzed. Twenty percent (33) of pregnancies resulted in fetal loss, 18% (31) in premature delivery and 62% (105) in a term infant. Maternal renal function declined, reversibly, in 3% (5) of pregnancies and in 48% (80) hypertension developed. In 53% (89) a significant increase in proteinuria occurred in pregnancy. Fetal and maternal complications of pregnancy occurred more frequently in patients with pre-existing hypertension although differences failed to reach statistical significance (p greater than 0.01). The presence of severe vessel lesions on the diagnostic renal biopsy was associated with a significantly higher fetal loss and prematurity rate (p less than 0.0005 and p less than 0.005, respectively).
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