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  • Title: [Pharmacokinetics and urinary excretion of aspoxicillin after consecutive administration at a dose of 4 grams].
    Author: Arakawa S, Matsui T, Maeda H, Sako M, Sugino M, Ka S, Nakasuji T, Fujii A, Kamidono S, Maezawa I.
    Journal: Jpn J Antibiot; 1988 Jan; 41(1):37-47. PubMed ID: 3367513.
    Abstract:
    Aspoxicillin (ASPC), a new injectable penicillin, was administered to 5 healthy male adult volunteers once a day at a daily dose of 4 g for 5 consecutive days to study its absorption and excretion. The results of this study are summarized as follows: 1. In consecutive administration of ASPC for 5 successive days, no remarkable changes were observed in serum concentrations and urinary excretion after each administration of ASPC. Therefore, no tendency of accumulation of the drug was recognized. 2. The serum ASPC concentration showed its peak values ranged from 212.3 to 224.8 micrograms/ml at completion of the intravenous drip infusion of ASPC. 3. Urinary recovery rates of ASPC ranged from 70 to 80%. 4. There were neither abnormal findings in subjective and objective symptoms nor abnormal values in physical and clinical laboratory test due to the administration of ASPC.
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