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  • Title: Secondary CIC-rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report.
    Author: Kimbara S, Imamura Y, Kiyota N, Takakura H, Matsumoto S, Koyama T, Fujishima Y, Funakoshi Y, Toyoda M, Hirose T, Kanzawa M, Kawamoto T, Hara H, Minami H.
    Journal: Mol Clin Oncol; 2021 Apr; 14(4):68. PubMed ID: 33680459.
    Abstract:
    Capicua transcriptional repressor (CIC)-rearranged sarcoma is an Ewing-like sarcoma with an aggressive clinical course and poor prognosis. No standard treatment has been established. The present study describes a case of CIC-rearranged sarcoma with lung metastases developing in a 24-year-old woman as a therapy-associated malignancy following chemotherapy for anaplastic large cell lymphoma at nine years old. This was treated with palliative regimens used for Ewing sarcoma. The patient achieved disease control for one year. Of note, ifosfamide and etoposide (IE), which were used as a second line treatment lead to a partial response. The case described in the present study indicated that treatment with Ewing regimens is a reasonable option for patients with metastatic CIC-rearranged sarcoma, including those with a second malignant case.
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