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  • Title: Rhein stimulates active chloride secretion in the short-circuited rat colonic mucosa.
    Author: Goerg KJ, Wanitschke R, Schwarz M, Meyer zum Büschenfelde KH.
    Journal: Pharmacology; 1988; 36 Suppl 1():111-9. PubMed ID: 3368509.
    Abstract:
    In a short-circuited mucosa-submucosa preparation of the rat descending colon with preserved Meissner's plexus mounted as an everted sac rhein transiently increased the potential difference and short-circuit current (Isc) when administered serosally and mucosally, but serosal application was more effective. Maximal effects were obtained at rhein concentrations of 1.6 X 10(-4) and 3 X 10(-4) mol/l. Net chloride absorption was decreased. Indomethacin (5 X 10(-6) mol/l) did not inhibit the increase of Isc, but omission of calcium from the serosal side as well as tetrodoxin (2 X 10(-7) mol/l) decreased it by 50 and 60%. Mechanical removal of Meissner's plexus partly blocked the effect of rhein, too. It is concluded that rhein stimulates colonic secretion by a direct action on the epithelial cells together with an indirect action via neurohumoral mechanisms.
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