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  • Title: [Enzyme system of initiation and protection against lipid peroxidation in the liver and blood of rats with hypokinesia].
    Author: Kukhta VK, Morozkina TS, Lisitsyna LP, Zakharenko IV, Mal'kovets IG.
    Journal: Vopr Med Khim; 1988; 34(1):19-22. PubMed ID: 3369122.
    Abstract:
    Content of lipid peroxidation products in liver mitochondria, enzymatic system of the peroxidation initiation (NADPH.H+- and NADH.H+-dependent oxydoreductases) at the early and final steps of liver microsomal redoxchain as well as the activity of protective enzymes superoxide dismutase, ceruloplasmin, catalase and glutathione reductase, preventing the excessive accumulation of lipid peroxidation products in liver mitochondria and erythrocytes were studied in rats with hypokinesia within 1 and 2 months. An increase in content of diene conjugates and malonic dialdehyde as well as in activity of NADPH.H+- and NADH.H+-nitroblue tetrazolium-oxydoreductases in liver microsomes, a decrease in activity of catalase and superoxide dismutase in liver mitochondria were observed in the animals within two months of their mobility restriction. These alterations were among the essential mechanisms responsible for an increase in content of lipid peroxidation products under conditions of hypokinesia.
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