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  • Title: Cardiomyopathy in the Kearns-Sayre syndrome.
    Author: Channer KS, Channer JL, Campbell MJ, Rees JR.
    Journal: Br Heart J; 1988 Apr; 59(4):486-90. PubMed ID: 3370184.
    Abstract:
    The Kearns-Sayre syndrome is a mitochondrial myopathy characterised by ptosis, chronic progressive external ophthalmoplegia, abnormal retinal pigmentation, and cardiac conduction defects. A unique case is reported in which there was rapid development of progressive congestive cardiac failure that required cardiac transplantation. A review of published reports of mitochondrial myopathy shows that a minority of cases (less than 20%) have cardiac involvement. This had previously been limited to abnormalities of cardiac conduction with progressive heart block. Myocardial biopsy has, however, shown ultrastructural evidence of a generalised mitochondrial disorder which hitherto has not been associated with a functional deficit.
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