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  • Title: Phase-linked modulation of excitability of presynaptic terminals of low-threshold afferent fibers in the inferior alveolar nerve during cortically induced fictive mastication in the guinea pig.
    Author: Kurasawa I, Hirose Y, Sunada T, Nakamura Y.
    Journal: Brain Res; 1988 Apr 12; 446(1):113-20. PubMed ID: 3370476.
    Abstract:
    Excitability of presynaptic terminals of low-threshold primary afferent fibers in the inferior alveolar nerve was tested in the trigeminal spinal nucleus of the ketamine-anesthetized, paralyzed guinea pig, by Wall's method. Fictive mastication was induced by repetitive stimulation of the cortical masticatory area, and was monitored by rhythmical burst activity in the jaw-opening anterior digastric motoneuron pool. The excitability was rhythmically modulated in a phase-linked manner during the masticatory cycle: it was decreased coincidentally with the digastric burst activity (jaw-opening phase) and increased during the middle and late periods of the interburst phase (jaw-closing phase) of the masticatory cycle. The results imply that presynaptic modulation of synaptic transmission of peripheral inputs from primary afferents to interneurons in the jaw-opening reflex pathway may contribute to the rhythmical modulation of the jaw-opening reflex evoked by innocuous stimulation of the intraoral structures during mastication; presynaptic inhibition contributing to the depression of the jaw-opening reflex during the jaw-closing phase and presynaptic facilitation to its enhancement during the jaw-opening phase.
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