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  • Title: [Effect of autologous skin paste on repairing wound of donor site of medium-thickness skin graft].
    Author: Mao HS, Wang YP, Wang Q, Wang WZ, Zhan WB, Ma JZ, Chou XG.
    Journal: Zhonghua Shao Shang Za Zhi; 2021 Mar 03; 37(3):1-5. PubMed ID: 33706433.
    Abstract:
    Objective: To explore the effect of autologous skin paste on repairing wound of medium-thickness skin donor site. Methods: The prospective randomized controlled research method was applied. From October 2018 to December 2019, 18 patients with flame burn or hydrothermal scald, met the inclusion criteria were admitted to Jinhua Hospital Affiliated to Zhejiang University School of Medicine, including 15 males and 3 females, aged (45±6) years, and the wounds were repaired with medium-thickness skin grafts. The wound area after medium-thickness skin grafting was (121±33) cm2. The wound of donor site of medium-thickness skin graft in each patient was divided into 2 wounds in equal area and included into autologous skin paste group and conventional treatment group with random number table, with 18 wounds in each group.The wounds in autologous skin paste group were repaired with skin paste prepared with remaining skin fragments after autologous medium-thickness skin grafting, and the wounds in conventional treatment group were repaired with petroleum jelly gauze and sterile gauze. On 3, 7, 14, 21 d after operation, the wound healing in 2 groups was observed, and the wound healing rate was calculated. The wound healing time in 2 groups was recorded. Occurrences of subcutaneous effusion and infection on 3, 7, 14, 21 d after operation and wound rupture in 3 months after operation were observed. In 6 months after operation, the Vancouver scar scale (VSS) was used to evaluate the scar formation of wounds in 2 groups. Data were statistically analyzed with analysis of variance for repeated measurement, chi-square test, and group t test. Results: The wounds in 2 groups did not heal on 3 and 7 d after operation. The wound healing rate in autologous skin paste group was (29.8±2.5)% and (95.6±4.7)% on 14 and 21 d after operation, which were significantly higher than (25.8±2.9)% and (82.6±8.9)% in conventional treatment group (t=4.3, 5.6, P<0.01). The wound healing time in autologous skin paste group was (21.8±1.4) d, which was significantly shorter than (25.6±2.0) d in conventional treatment group (t=6.24, P<0.01). On 3, 7, 14, 21 d after operation, there were no complications such as subcutaneous effusion and infection in wounds of 2 groups. In 3 months after operation, ulceration occurred in wounds of 2 patients in autologous skin paste group, which was significantly less than 12 patients in conventional treatment group (χ2=11.688, P＜0.01). The wounds with ulceration healed after dressing change. In 6 months after operation, the VSS score of wounds in autologous skin paste group was (9.1±1.1) points, which was significantly lower than (11.3±1.2) points in conventional treatment group (t=-5.75, P＜0.01). Conclusion: The remaining fragments after autologous medium-thickness skin grafting are prepared into skin paste to repair wound of donor site of medium-thickness skin graft can shorten wound healing time, improve wound healing quality, reduce degree of scar hyperplasia, which has a good clinical effect. 目的： 探讨自体皮浆修复中厚皮供皮区创面的效果。 方法： 采用前瞻性随机对照研究方法。2018年10月—2019年12月，浙江大学医学院附属金华医院收治符合入选标准的火焰烧伤或热液烫伤患者18例，其中男15例、女3例，年龄（45±6）岁， 采用大腿中厚皮修复。中厚皮切取后形成面积为（121±33）cm2创面。将每例患者中厚皮供区创面分成面积相等的2个创面，采用随机数字表法分为自体皮浆组和常规治疗组，每组各18个创面。自体皮浆组创面采用由自体中厚皮移植后剩余的碎皮片制成的皮浆治疗，常规治疗组创面常规凡士林纱布、无菌纱布包扎固定。术后3、7、14、21 d，观察2组创面愈合情况，并计算创面愈合率。记录2组创面愈合时间。术后3、7、14、21 d，观察2组创面皮下积液及感染等发生情况；术后3个月，观察2组创面破溃等发生情况。术后6个月，采用温哥华瘢痕量表（VSS）评分评估2组创面瘢痕形成情况。对数据行重复测量方差分析、χ2检验、成组t检验。 结果： 2组创面术后3、7 d均未见愈合。自体皮浆组术后14、21 d创面愈合率分别为（29.8±2.5）%、（95.6±4.7）%，明显高于常规治疗组的（25.8±2.9）%、（82.6±8.9）% ，t=4.3、5.6，P＜0.01。自体皮浆组创面愈合时间为（21.8±1.4）d，明显短于常规治疗组的（25.6±2.0）d，t=6.24，P＜0.01。 术后3、7、14、21 d，2组创面均未发生皮下积液及感染等并发症。术后3个月，自体皮浆组创面愈合后2例发生破溃，明显少于常规治疗组的12例（χ2=11.688，P＜0.01），破溃创面经常规换药后愈合。术后6个月，自体皮浆组创面VSS评分为（9.1±1.1）分，明显低于常规治疗组的（11.3±1.2）分，t=-5.75，P＜0.01。 结论： 将自体中厚皮移植后剩余的碎皮片制备成皮浆，回植中厚皮供区创面能有效缩短创面愈合时间，提高创面愈合质量，减少瘢痕增生程度，具有较好的临床效果。.
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