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  • Title: The cholecystokinin antagonist L-364,718 inhibits the action of cholecystokinin but not bombesin on rat pancreatic secretion in vivo.
    Author: Anderson L, Dockray GJ.
    Journal: Eur J Pharmacol; 1988 Feb 09; 146(2-3):307-11. PubMed ID: 3371402.
    Abstract:
    The action of an antagonist of peripheral CCK receptors, L-364,718 on CCK8 and bombesin-induced pancreatic exocrine secretion was studied in anaesthetized rats. Both CCK8 and bombesin increased the rate of flow and rate of enzyme secretion from the pancreas. Intravenous L-364,718 inhibited the actions of CCK8, but not those of bombesin. It is concluded that bombesin acts on the exocrine pancreas directly rather than through the release of CCK.
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