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  • Title: Maternal stress alters monoamine metabolites in fetal and neonatal rat brain.
    Author: Herrenkohl LR, Ribary U, Schlumpf M, Lichtensteiger W.
    Journal: Experientia; 1988 May 15; 44(5):457-9. PubMed ID: 3371452.
    Abstract:
    Heat-restraint stress given rats during the last week of gestation significantly altered dopaminergic dihydroxyphenylacetic acid and homovanillic acid (DOPAC and HVA) and noradrenergic 3-methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG) forebrain-hypothalamic monoamine (MA) metabolites in female offspring. On gestational day 21, HVA and MOPEG were significantly higher and lower, and on postnatal day 1 all were higher. There were virtually no differences in brain MA concentrations in males. Thus MA metabolic concentrations differ in fetal-neonatal forebrain-hypothalamus as a function of sex differences and maternal stress.
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