These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Visual disorders caused by diphenylhydantoin: clinical and electro-ophthalmologic findings].
    Author: Lorenz R, Kuck H.
    Journal: Klin Monbl Augenheilkd; 1988 Mar; 192(3):244-7. PubMed ID: 3374014.
    Abstract:
    In 1981 a 47-year-old white woman was given a total of 9 g of DPH for treatment of epilepsy. A rare hereditary defect in the metabolism of this drug caused toxic blood levels for about three months and led to persistent neurologic and ophthalmologic disturbances. In addition to an atrophy of the cerebellum, demonstrated by a CT scan, the predominant ophthalmologic findings were bilateral reduced visual acuity (0.1) and restricted visual fields (15 degrees). Despite intensive clinical and electrophysiologic investigations it proved impossible to localize the site of damage in the ascending visual pathway. Only VECP to patterns of low contrast (0.2) exhibited a pathologic response. It was concluded that persistent visual disturbances due to DPH intoxication are caused by a more centrally located action of this drug.
    [Abstract] [Full Text] [Related] [New Search]