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  • Title: [Blood flow in normal and tumor tissue during hyperthermia].
    Author: Kurpeshev OK, Konopliannikov AG.
    Journal: Med Radiol (Mosk); 1988 May; 33(5):26-31. PubMed ID: 3374300.
    Abstract:
    The authors reported the results of measurements of the blood flow in subcutaneous fat and 3 types of tumors (sarcoma 37, Lewis carcinoma, melanoma B16) by a thermoelectric method during local hyperthermia of mouse limbs. In the first minutes of exposure the blood flow rate increased reaching a plateau in 25-35 min. Changes in the blood flow grew with raising the temperature of heating, and they were more noticeable for normal tissues than for tumorous ones. The blood flow enhancement varied in different tumors: the highest in sarcoma 37, and the lowest in melanoma B16. In some tumors after prolonged heating (over 30 min.) and at high temperature (44 degrees C) a maximum increase in the blood flow was followed by its weakening.
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