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Title: Gender and age-specific reference intervals of common biochemical analytes in Chinese population: Derivation using real laboratory data.
Author: Wang D, Ma C, Zou Y, Yu S, Li H, Cheng X, Qiu L, Xu T.
Journal: J Med Biochem; 2020 Sep 02; 39(3):384-391. PubMed ID: 33746609.
Abstract:
BACKGROUND: Indirect sampling methods are not only inexpensive but also efficient for establishing reference intervals (RIs) using clinical data. This study was conducted to select fully normal records to establish ageand gender-specific RIs for common biochemical analytes by laboratory data mining. METHODS: In total, 280,206 records from 2014 to 2018 were obtained from Peking Union Medical College Hospital. Common biochemical analytes total protein, albumin, total bilirubin (TBil), direct bilirubin (DBil), alanine aminotransferase (ALT), glutamyltranspeptidase (GGT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), potassium, sodium, chlorine, calcium, urea, glucose, uric acid (UA), inorganic phosphorus, creatinine (Cr), total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol] were measured using an automatic analyzer. Sources of variation were identified by multiple regression analysis. The 2.5th and 97.5th percentiles were calculated as the lower and upper limits of the RIs, respectively. RESULTS: Gender was the major source of variation among the 13 common biochemical analytes with an rp > 0.15. In contrast to the value listed in the WS/T 404, nearly all RIs established in this study were significantly narrower. Furthermore, age-specific RIs should be determined for DBil, LDH, and urea, whereas gender-specific RIs are suggested for GGT, LDH, and urea. CONCLUSIONS: We recommend that gender-specific RIs should be established for ALT, AST, GGT, DBil, TBil, UA, and Cr as well as genderand age-specific RIs for urea and ALP. Through indirect sampling, ageand gender-specific RIs for common biochemical analytes were established and analyzed. UVOD: Metode indirektnog uzorkovanja nisu samo jeftine, već su i efikasne za uspostavljanje referentnih intervala (RI) korišćenjem velike količine kliničkih podataka. Ova studija je sprovedena sa ciljem da se odaberu potpuno normalni pojedinačni zapisi da bi se utvrdio RI za starost i pol za zajedničke biohemijske analite pomoću laboratorijski dobijenih podataka. METODE: Ukupno je uzeto 280.206 pojedinačnih rezultata u periodu od 2014. do 2018. godine iz bolnice Peking Union Medical College-a. Uobičajeni biohemijski analiti [ukupni protein, albumin, ukupni bilirubin (TBil), direktni bilirubin (DBil), alanin aminotransferaza (ALT), glutamiltranspeptidaza (GGT), alkalna fosfataza (ALP), aspartat aminotransferaza (AST), laktat dehidrogenaza (LAT) kalijum, natrijum, hlor, kalcijum, ureja, glukoza, mokraćna kiselina (UA), neorganski fosfor, kreatinin (Cr), ukupni hole sterol, trigliceridi, lipoprotein holesterola visoke gustine i lipoprotein holesterola niske gustine] mereni su korišćenjem automatskog analizatora. Izvori varijacije identifikovani su višestrukom regresionom analizom. Postoci (2,5 i 97,5) su izračunati kao donja i gornja granica RI, svaki ponaosob. REZULTATI: Pol je bio glavni izvor varijacije među 13 uobičajenih biohemijskih analita sa rp > 0,15. Za razliku od vrednosti navedene u WS / T 404, skoro svi RI utvrđeni u ovoj studiji bili su znatno uži. Dalje, za DBil, LDH i ureju trebalo bi odrediti RI specifične za starost, dok su za GGT, LDH i ureu, starosni referentni intervali predloženi. ZAKLJUČAK: Preporučujemo da se utvrde referentni intervali specifični za pol za ALT, AST, GGT, DBil, TBil, UA i Cr, kao i referentni intervali specifični za pol i starost za ureju i ALP. Kroz indirektno uzorkovanje utvrđeni su i analizirani referentni intervali specifični za starosnu dob i za zajedničke biohemijske analite.

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