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  • Title: Cytogenetic analysis of 688 couples experiencing multiple spontaneous abortions.
    Author: Castle D, Bernstein R.
    Journal: Am J Med Genet; 1988 Mar; 29(3):549-56. PubMed ID: 3376998.
    Abstract:
    We report on cytogenetic analysis of 688 couples experiencing two or more first- and/or second-trimester abortions (less than 20 weeks). The overall abnormality rate was 6.83% (47 couples). However, exclusion of those anomalies not generally accepted as being causal in spontaneous abortion leaves an abnormality rate of only 2.33% (16 couples). We discuss the significance of balanced translocations, inversions, sex chromosome aneuploidies, and mosaicisms thereof in the causation of multiple abortions.
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