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  • Title: Metal-organic framework precursors derived Ni-doping porous carbon spheres for sensitive electrochemical detection of acetaminophen.
    Author: Guo L, Hao L, Zhang Y, Yang X, Wang Q, Wang Z, Wang C.
    Journal: Talanta; 2021 Jun 01; 228():122228. PubMed ID: 33773732.
    Abstract:
    The sensitive and selective determination of acetaminophen (AP) in the human body is highly desirable to ensure human health. In this work, nickel-doping nanoporous carbon (Ni/C) was fabricated by directly calcining Ni based metal-organic framework (Ni-MOF). The Ni/C based electrochemical sensor was developed for sensitive and selective determination of AP in human blood serum and urine samples. The prepared Ni/C composite possess plentiful catalytic active sites, ordered mesoporous structure and large specific surface area, which endow the constructed Ni/C sensor with a prominent performance for acetaminophen sensing. Under the optimal conditions, the developed method offered good linearity in the range of 0.20-53.75 μM with a low detection limit (S/N = 3) of 4.04 × 10-2 μM. The electrocatalytic performance of the sensor towards AP was further measured by differential pulse voltammetry and cyclic voltammetry. The results demonstrated that the Ni/C sensor can be feasibly employed for the determination of AP in human blood serum and urine samples with excellent anti-interference stability and good reproducibility. The research reveals a great promising of the Ni/C electrochemical sensor for clinical applications and paves a way for the construction of high-performance electrochemical sensors for AP determination.
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