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  • Title: Differential effects of calcium channel blocking agents on pancuronium- and suxamethonium-induced neuromuscular blockade.
    Author: Salvador A, del Pozo E, Carlos R, Baeyens JM.
    Journal: Br J Anaesth; 1988 Apr; 60(5):495-9. PubMed ID: 3377924.
    Abstract:
    The effects were studied of several calcium channel blocking agents on muscle twitch, and possible interactions between these drugs and pancuronium and suxamethonium, using a rat phrenic-hemidiaphragm preparation. Nicardipine, verapamil and diltiazem each caused a concentration-related depression of muscle response. Nicardipine had the most, and diltiazem the least, potent effect. Verapamil and diltiazem 5 and 10 mumol litre-1 caused a concentration-dependent enhancement of suxamethonium-induced neuromuscular blockade, but increased the effect of pancuronium only at 10 mumol litre-1. Nicardipine 10 mumol litre-1 significantly enhanced pancuronium-induced neuromuscular blockade, but not that produced by suxamethonium.
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