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  • Title: Tailored Mobility in a Zeolite Imidazolate Framework (ZIF) Antibody Conjugate*.
    Author: Chapartegui-Arias A, Raysyan A, Belenguer AM, Jaeger C, Tchipilov T, Prinz C, Abad C, Beyer S, Schneider RJ, Emmerling F.
    Journal: Chemistry; 2021 Jun 25; 27(36):9414-9421. PubMed ID: 33786901.
    Abstract:
    Zeolitic imidazolate framework (ZIF) hybrid fluorescent nanoparticles and ZIF antibody conjugates have been synthesized, characterized, and employed in lateral-flow immunoassay (LFIA). The bright fluorescence of the conjugates and the possibility to tailor their mobility gives a huge potential for diagnostic assays. An enzyme-linked immunosorbent assay (ELISA) with horseradish peroxidase (HRP) as label, proved the integrity, stability, and dispersibility of the antibody conjugates, LC-MS/MS provided evidence that a covalent link was established between these metal-organic frameworks and lysine residues in IgG antibodies.
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