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  • Title: [Study of an articular cartilage in rheumatoid arthritis by the immunofluorescence method].
    Author: Rusakova MS, Gritsman NN, Speranskiĭ AI, Mirzoeva SM?.
    Journal: Arkh Patol; 1977; 39(9):36-43. PubMed ID: 337940.
    Abstract:
    The immunomorphological examinations of 20 biopsy specimens of articular cartilage in rheumatoid arthritis at various stages of the pathological process showed immunoglobulins of different classes and complement (C'3) to penetrate into the articular cartilage. In early stages mostly IgG was detected, and with increasing destructive processes in the matrix IgM was found. A certain tropism in the distribution of immunoglobulins in the cartilage matrix to the zones of chondrocytic capsules was observed which could be associated with the direction of immune reactions towards chondrocytes. The articular cartilage tissue may be the basis for the development of the autoimmune process and maintain permanent inflammatory process in the synovial membrane of the joint with local antibody synthesis. The process of phagocytosis of the antigenic substances of the articular cartilage or immune complexes deposed in it underlies the distribution of pannus.
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