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  • Title: Intra-hypothalamic melatonin blocks photoperiodic responsiveness in the male Syrian hamster.
    Author: Hastings MH, Walker AP, Roberts AC, Herbert J.
    Journal: Neuroscience; 1988 Mar; 24(3):987-91. PubMed ID: 3380310.
    Abstract:
    Exposure of male Syrian hamsters to a short daylength of 8L:16D leads to gonadal regression. This effect of photoperiod was prevented by pinealectomy or chronic exposure of the brain to exogenous melatonin delivered from in-dwelling cannulae. However, the effect of melatonin was dependent on the neural site of application. Melatonin delivered into the mid-brain, lateral hypothalamus or amygdala was ineffective. In contrast, bilateral administration of melatonin to the medial or amygdala was ineffective. In contrast, bilateral administration of melatonin to the medial hypothalamus prevented testicular regression and maintained high circulating levels of luteinizing hormone and prolactin. These findings suggest that the medial hypothalamus contains target sites for melatonin involved in pineal-mediated photoperiodic responses.
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