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  • Title: Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains.
    Author: Nordberg A, Adem A, Hardy J, Winblad B.
    Journal: Neurosci Lett; 1988 Apr 12; 86(3):317-21. PubMed ID: 3380323.
    Abstract:
    Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.
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