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  • Title: Bias current modifies the selectivity of liquid membrane ion-selective microelectrodes.
    Author: Coles JA.
    Journal: Pflugers Arch; 1988 Mar; 411(3):339-44. PubMed ID: 3380648.
    Abstract:
    A negative bias potential of up to -80 mV applied to the back of a liquid membrane ion-selective microelectrode containing classical "K+" ion-exchanger was found to make it more selective for millimolar concentrations of K+ over micromolar concentrations of choline, tetramethylammonium, tetraethylammonium and 5-hydroxytryptamine. Conversely, positive bias potential increased severalfold the sensitivity to micromolar concentrations of these ions while decreasing the sensitivity to K+. An increase in response amplitude for millimolar changes of ion concentration was also observed in neutral carrier electrodes for Na+, K+ and Ca2+ with negative bias potential. The various ions caused the resistances of the electrodes to change; these resistance changes contributed to the changes in response amplitude, but there were additional, unexplained, factors. The phenomenon was used to test if the signal from a K+ ion-exchanger microelectrode in extracellular space in bee retina was contaminated by substances other than K+.
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