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  • Title: Isomers of 10-hydroxynortriptyline in geriatric depression.
    Author: Young RC, Dhar AK, Kutt H, Alexopoulos GS.
    Journal: Ther Drug Monit; 1988; 10(2):164-7. PubMed ID: 3381232.
    Abstract:
    In geriatric, depressed inpatients treated with nortriptyline (NT), total unconjugated plasma concentrations of the Z isomer of the 10-hydroxylated metabolite (10-OH-NT) were determined simultaneously with concentrations of the E isomer by high-performance liquid chromatography. Z-10-OH-NT concentrations averaged 14% of E-10-OH-NT concentrations.
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