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  • Title: Controlled field trial of a high-dose oral killed typhoid vaccine in India.
    Author: Chuttani CS, Prakash K, Gupta P, Grover V, Kumar A.
    Journal: Bull World Health Organ; 1977; 55(5):643-4. PubMed ID: 338191.
    Abstract:
    A controlled field trial of a modified vaccine containing Salmonella typhi, TY 2 strain, in a dose of 400 x 10(9) killed organisms per capsule, was carried out in schoolchildren aged 6-17 years. The children were followed up for 6-8 months. There were 66 cases of typhoid fever in the vaccine group (7312 children) and 54 in the control group (7292 children who had received a placebo). This difference is not statistically significant. The results confirm that, as found in earlier trials, oral typhoid vaccine, in the dosages used so far, gives no protection.
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