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  • Title: Central nervous system relapse in a child with anaplastic large cell lymphoma: potential for new therapeutic strategies.
    Author: Raffa EH, Branson HM, Ngan B, Alexander S, Abla O.
    Journal: Cancer Rep (Hoboken); 2021 Oct; 4(5):e1377. PubMed ID: 33822480.
    Abstract:
    BACKGROUND: Central nervous system (CNS) relapse is rare in childhood anaplastic large cell lymphoma (ALCL) and is associated with a poor prognosis. CASE: We describe an 8-year-old boy with ALCL who developed an early CNS relapse without initial CNS disease. Despite aggressive medical management, the patient's neurological status deteriorated rapidly and he died shortly after. CONCLUSION: Optimal treatment for children with relapsed ALCL involving the CNS remains unclear. Novel agents, including ALK inhibitors, that have CNS-penetration might be helpful and pediatric studies are warranted.
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