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  • Title: Novel compounds from Premna herbacea Roxb. with antidiabetic potential.
    Author: Manikanth G, Viswambharan AI, Mathad P.
    Journal: Pak J Pharm Sci; 2020 Sep; 33(5):1971-1979. PubMed ID: 33824103.
    Abstract:
    Diabetes mellitus is an epidemic that is growing worldwide at an alarming rate. The need for plant-based drugs to combat this epidemic led to the isolation of three new compounds, namely 1-Benzoyloxy-8-tetradecanoyloxy-geranilane (1), 1-Benzoyloxy-8-(octadec-9ꞌꞌ-enoyl) geranilane (2), and 1-Benzoyloxy-8-octadecanoyloxygeranilane (3), from the roots of Premnaherbacea. Their structures were deciphered by 1H NMR, 13C NMR, and 2D-NMR. In vitro (α-amylase and α-glucosidase inhibitory activity) and in vivo antidiabetic activity (streptozotocin- nicotinamide model) were conducted using various groups for which various biochemical parameters and histopathology studies were done. This study confirmed that 1-Benzoyloxy-8-(octadec-9ꞌꞌ-enoyl) geranilane from roots of Premna herbacea have significant antidiabetic and antioxidant activity, thus indicating a corrective effect on diabetes and its complications.
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