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  • Title: Inhibition of rat liver glutathione S-transferase isoenzymes by acrolein.
    Author: Scott TR, Kirsch RE.
    Journal: Biochem Int; 1988 Mar; 16(3):439-42. PubMed ID: 3382415.
    Abstract:
    The in vitro effect of the toxin and teratogen, acrolein, on the fetal rat liver glutathione S-transferase isoenzyme, YcYfetus, was investigated and compared with acrolein's effect on some of the adult rat liver glutathione S-transferase isoenzymes. Acrolein was found to inhibit all the isoenzymes investigated and double-reciprocal plots suggest that inhibition is either noncompetitive or mixed-type noncompetitive. It is therefore attractive to suggest that should a similar situation arise in vivo, it may provide one mechanism for the teratogenicity of acrolein.
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