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  • Title: [Synthesis of peptides catalyzed by papain in organic solvents with minimal water content].
    Author: Mitin IuV, Schellenberger F.
    Journal: Bioorg Khim; 1988 Jan; 14(1):5-9. PubMed ID: 3382433.
    Abstract:
    Synthesis of a model peptide, Z-Ala-Val-OBut, catalyzed by papain in acetonitrile containing 0-5% water was studied. Z-Ala-OCH2CONH2 was used as a carboxyl component. The optimal concentration of water was found to be 0.3-0.5%. Under these conditions the reaction rate is 50 to 100 times lower than in water but the yield of the peptide can be as high as 99.5%. Effect of reagent concentrations and temperature on the reaction was also studied.
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