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  • Title: Lanthanide-stimulated glucose and proline transport across rabbit intestinal brush-border membranes.
    Author: Stevens BR, Kneer C.
    Journal: Biochim Biophys Acta; 1988 Jul 07; 942(1):205-8. PubMed ID: 3382657.
    Abstract:
    Trivalent cations of the lanthanide series (La3+----Yb3+) stimulated uptake of proline or glucose in rabbit small intestinal brush-border membrane vesicles. The lanthanides stimulated uptake to an extent greater than Al3+, choline, and in many cases, Na+. A time-course of Er3+-stimulated glucose uptake gave initial rates and overshoots greater than Na+ stimulation. The best activators were Sm3+, Eu3+ and Tm3+, which stimulated proline initial uptakes by 400-600%, and stimulated glucose uptake by 120-150%, compared to Na+. The best lanthanide cotransport activators possessed high third ionization potentials.
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