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  • Title: [Antihistaminic and antiserotonin properties of new complex tropine esters].
    Author: Mashkovskiĭ MD, Shvarts GIa.
    Journal: Farmakol Toksikol; 1979; 42(1):3-7. PubMed ID: 33829.
    Abstract:
    The antihistaminic and antiserotonin properties of 16 new tropine esters, analogues of atropine, tropacin and tropaphen, were studied. All of them were found to lessen the spasmogenic effects of histamine and serotonin. The intensity of the antihistaminic and antiserotonin action of the drugs varied depending upon the structure of the radical at the alpha-carbon atom in the acidic part of the molecule. Both types of the activity are most marked in the desoxymethyl propyl and butyl analogues of atropine. The absence of the oxymethyl group at alpha-carbon in the series of atropine analogues is shown to facilitate the manifestation of the antihistaminic activity.
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