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  • Title: A comparison of maprotiline (Ludiomil) and amitriptyline (2).
    Author: Mindham BA.
    Journal: J Int Med Res; 1977; 5 Suppl 4():25-33. PubMed ID: 338399.
    Abstract:
    Seventy-five patients were admitted to a double-blind multicentre trial of maprotiline (Ludiomil) and amitriptyline in the management of depression in general practice. Forty-seven patients, twenty-one on maprotiline and twenty-six on amitriptyline completed the study. Statistical analysis of admission data showed that the groups were not strictly comparable in that the maprotiline group contained many more males and had a greater average age. Nevertheless, although there was a suggestion that amitriptyline was faster-acting in the younger age group that received it, there were no statistically significant differences between the two treatment groups as regards onset of effect, clinical efficacy or tolerability.
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