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  • Title: Spontaneous Remission of Thrombospondin Type-1 Domain-Containing-Associated Membranous Nephropathy.
    Author: Watanabe S, Suzuki T, Han W, Nakata M, Koitabashi K, Ichikawa D, Kamijo-Ikemori A, Koike J, Shibagaki Y.
    Journal: Intern Med; 2021 Oct 01; 60(19):3125-3128. PubMed ID: 33840692.
    Abstract:
    Membranous nephropathy often achieves spontaneous remission. However, there are scarce reports of spontaneous remission of thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy. A 64-year-old female presented with nephrotic syndrome and edema of the lower extremities. We diagnosed membranous nephropathy by kidney biopsy and confirmed positive THSD7A on immunofluorescence using frozen sections; serum THSD7A antibodies were also detected. Thirty-four months after the initial diagnosis, she achieved a spontaneous complete remission without immunosuppressive therapy. With the complete remission, no serum THSD7A levels were detected. In this study, we describe serial examinations of kidney biopsies and serum THSD7A antibodies.
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